A Comparative Study of the Water Drinking Test in Eyes With Open-Angle Glaucoma and Prior Trabeculectomy or Tube Shunt. Issue 2 (February 2017)

• Record Type: Journal Article
• Authors: Martinez, Patricia; Trubnik, Valerie; Leiby, Benjamin E.; Hegarty, Sarah E.; Razeghinejad, Reza; Savant, Shravan; Myers, Jonathan S.
• Is Part Of: Journal of glaucoma. Volume 26:Issue 2(2017)
• Publication Date: 2017-02
• Subjects: water drinking test -- trabeculectomy -- tube shunt surgery -- intraocular pressure -- glaucoma; Glaucoma -- Periodicals; 617.741005
• DOI: 10.1097/IJG.0000000000000589
• Languages: English
• ISSNs: 1057-0829

Abstract

Abstract : Purpose: To compare the intraocular pressure (IOP) response after the water drinking test (WDT) in patients who have undergone trabeculectomy or tube shunt surgery. Methods: This prospective study examined 40 eyes of 34 open-angle glaucoma subjects who had undergone trabeculectomy (n=20) or tube shunt surgery (n=20). Both groups were matched by IOP range and by number of topical antiglaucoma medications used. After a baseline IOP assessment, subjects drank 10 mL water per kg body weight over 15 minutes. IOP was then measured with a Goldman tonometer every 15 minutes over a 1-hour period. Outcomes measures were IOP peak, fluctuation, mean, and range. Results: No significant differences in baseline demographics, baseline clinical characteristics or IOP changes during the WDT were observed between the 2 surgical procedure groups. Mean baseline IOPs for the tube shunt and trabeculectomy groups were 12.55±4.23 and 12.3±4.28 mm Hg, respectively ( P =0.854). In the trabeculectomy and tube shunt groups, respectively, peak IOP was 16.25±5.55 and 16.15±5.36 mm Hg ( P =0.954); IOP fluctuation (IOP max—IOP baseline) was 3.95±2.17 and 3.6±2.23 mm Hg ( P =0.618), and IOP range was 2.78±1.56 and 2.8±1.47 mm Hg ( P =0.959). Statistical analysis of IOP fluctuation associations using multivariable linear regression determined that the use of systemic antihypertensive blood pressure medication was associated with an increase in IOP fluctuation of approximately 2 mm Hg. Conclusions: Subjects who had undergone either trabeculectomy or tube shunt surgery showed a similar IOP response to the WDT. Subjects on systemic antihypertensive medications experienced significantly greater IOP fluctuations during the test.