Correction of factor XI deficiency by liver transplantation. Issue 8 (December 2015)

• Record Type: Journal Article
• Authors: Gupta, Eva; Finn, Laura; Johns, Gretchen; Pruthi, Rajiv K.; Roy, Vivek
• Is Part Of: Blood coagulation and fibrinolysis. Volume 26:Issue 8(2015)
• Publication Date: 2015-12
• Subjects: bleeding -- clotting factors -- factor XI deficiency -- hemophilia -- liver transplant; Blood -- Coagulation -- Periodicals; Fibrinolysis -- Periodicals; Hemostasis -- Periodicals; Thrombosis -- Periodicals; Blood Coagulation -- Periodicals; Fibrinolysis -- Periodicals; Hemostasis -- Periodicals; Thrombosis -- Periodicals; 612.115
• DOI: 10.1097/MBC.0000000000000344
• Languages: English
• ISSNs: 0957-5235

Abstract

Abstract : Orthotopic liver transplantation for other diseases typically results in a coincidental cure for hemophilia A and B; however, long-term outcomes of liver transplant in hemophilia C are not very well described. Herein, the authors report a patient of severe congenital factor XI (FXI) deficiency who received an orthotopic liver transplant. The authors discuss the perioperative management and long-term outcomes. The normalization of his FXI levels confirms that the liver is the most clinically relevant site of synthesis of FXI.