Fluid-Attenuated Inversion Recovery Vascular Hyperintensities–Diffusion-Weighted Imaging Mismatch Identifies Acute Stroke Patients Most Likely to Benefit From Recanalization. Issue 2 (February 2016)

• Record Type: Journal Article
• Authors: Legrand, Laurence; Tisserand, Marie; Turc, Guillaume; Edjlali, Myriam; Calvet, David; Trystram, Denis; Roca, Pauline; Naggara, Olivier; Mas, Jean-Louis; Méder, Jean-Francois; Baron, Jean-Claude; Oppenheim, Catherine
• Is Part Of: Stroke. Volume 47:Issue 2(2016)
• Publication Date: 2016-02
• Subjects: infarction -- magnetic resonance angiography -- magnetic resonance imaging -- perfusion imaging -- thrombolysis; Cerebrovascular disease -- Periodicals; Cerebral circulation -- Periodicals; 616.81
• DOI: 10.1161/STROKEAHA.115.010999
• Languages: English
• ISSNs: 0039-2499

Abstract

Abstract : Background and Purpose—: Fluid-attenuated inversion recovery vascular hyperintensities (FVH) beyond the boundaries of diffusion-weighted imaging (DWI) lesion (FVH-DWI mismatch) have been proposed as an alternative to perfusion-weighted imaging (PWI)-DWI mismatch. We aimed to establish whether FVH-DWI mismatch can identify patients most likely to benefit from recanalization. Methods—: FVH-DWI mismatch was assessed in 164 patients with proximal middle cerebral artery occlusion before intravenous thrombolysis. PWI-DWI mismatch (PWITmax>6sec /DWI>1.8) was assessed in the 104 patients with available PWI data. We tested the associations between 24-hours complete recanalization on magnetic resonance angiography and 3-month favorable outcome (modified Rankin Scale score ⩽2), stratified on FVH-DWI (or PWI-DWI) status. Results—: FVH-DWI mismatch was present in 121/164 (74%) patients and recanalization in 50/164 (30%) patients. The odds ratio for favorable outcome with recanalization was 16.2 (95% confidence interval, 5.7–46.5; P <0.0001) in patients with FVH-DWI mismatch and 2.6 (95% confidence interval, 0.6–12.1; P =0.22) in those without FVH-DWI mismatch ( P =0.048 for interaction). Recanalization was associated with favorable outcome in patients with PWI-DWI mismatch (odds ratios, 9.9; 95% confidence interval, 3.1–31.3; P =0.0001) and in patients without PWI-DWI mismatch (odds ratios, 7.0; 95% confidence interval, 1.1–44.1; P =0.047), P =0.76 for interaction. Conclusion—: The FVH-DWI mismatch may rapidly identify patients with proximal occlusion most likely to benefit from recanalization.