First Use of Investigational Antiviral Drug Pocapavir (V-073) for Treating Neonatal Enteroviral Sepsis. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Torres-Torres, Sanet; Myers, Angela L.; Klatte, J. Michael; Rhoden, Eric E.; Oberste, M. Steven; Collett, Marc S.; McCulloh, Russell J.
• Is Part Of: Pediatric infectious disease journal. Volume 34:Issue 1(2015)
• Publication Date: 2015-01
• Subjects: neonatal enterovirus infection -- pocapavir -- coxsackievirus; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000000497
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : Neonatal enteroviral sepsis is a potentially fatal condition. Perinatally acquired infection and severe coagulopathy can be associated with a poor clinical outcome, and antiviral therapy is currently unavailable. Pocapavir (V-073) is an investigational drug candidate being developed for poliovirus indications, but also has variable antiviral activity against nonpolio enteroviruses. We describe the first use of pocapavir in treating a case of severe neonatal enteroviral sepsis due to Coxsackievirus B3.