Early antiretroviral therapy reduces HIV DNA following perinatal HIV infection. (24th August 2017)

• Record Type: Journal Article
• Authors: Foster, Caroline; Pace, Matthew; Kaye, Steve; Hopkins, Emily; Jones, Mathew; Robinson, Nicola; Mant, Christine; Cason, John; Fidler, Sarah; Frater, John
• Is Part Of: AIDS. Volume 31:Number 13(2017)
• Publication Date: 2017-08-24
• Subjects: early antiretroviral therapy -- HIV reservoir -- perinatally infected children; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome; AIDS (Disease); Periodicals; Periodicals; 616.9792005
• DOI: 10.1097/QAD.0000000000001565
• Languages: English
• ISSNs: 0269-9370

Abstract

Abstract : N/A: The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterized in perinatally acquired infection. In a prospective observational study of 20 children with perinatally acquired infection and sustained viral suppression on ART for more than 5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients ( P = 0.0062), and correlated with age of initiation ( P = 0.13; r = 0.57). No difference was seen in cell-associated viral RNA ( P = 0.36). Identifying paediatric populations with smaller reservoirs may inform strategies with potential to induce ART-free remission. Abstract : Supplemental Digital Content is available in the text