Concomitant use of argatroban and warfarin during hemodialysis in heparin-induced thrombocytopenia. (January 2015)

• Record Type: Journal Article
• Authors: Vianello, Fabrizio; Furian, Lucrezia; Nordio, Maurizio; Treleani, Martina; Fabris, Fabrizio
• Is Part Of: Hematology. Volume 20(2015)Supplement 1
• Page Start: 48
• Page End: 49
• Publication Date: 2015-01
• Subjects: Heparin-induced thrombocytopenia -- Hemodialysis -- Argatroban; Blood -- Diseases -- Periodicals; Hematology -- Periodicals; Blood -- Transfusion -- Periodicals; 616.15005
• DOI: 10.1179/1607845414Y.0000000157
• Languages: English
• ISSNs: 1024-5332

Abstract

Abstract : Objective and importance: The use of argatroban during hemodialysis in a patient receiving warfarin is not established. We present a case of heparin-induced thrombocytopenia in a patient on hemodialytic therapy who successfully received argatroban concomitantly to warfarin during renal replacement therapy. Clinical presentation: A 46-year-old male patient with autosomal dominant polycystic kidney disease presented with heparin-induced thrombocytopenia (HIT) arised during dialytic procedures. Intervention: After the acute episode requiring argatroban and warfarin therapy, the patient continued to receive argatroban during the hemodialytic session concomitantly to warfarin. Conclusion: The administration of argatroban in the dialytic circuit of a patient on oral anticoagulant therapy can be considered an effective and safe approach.