Cavity-containing supramolecular gels as a crystallization tool for hydrophobic pharmaceuticals. Issue 66 (4th July 2016)

• Record Type: Journal Article
• Authors: Kaufmann, Lena; Kennedy, Stuart R.; Jones, Christopher D.; Steed, Jonathan W.
• Is Part Of: Chemical communications. Volume 52:Issue 66(2016)
• Page Start: 10113
• Page End: 10116
• Publication Date: 2016-07-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc04037c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We present two approaches to low-molecular-weight supramolecular gels bearing hydrophobic cavities based on calixarene-containing building blocks. Abstract : We present two approaches to low-molecular-weight supramolecular gels bearing hydrophobic cavities based on calixarene-containing building blocks. Gels are formed by a calixarene based tetrahydrazide gelator or a co-gel of a calixarene diammonium salt and a bis-crown ether. The calixarene hydrophobic cavity enables the complexation of hydrophobic drug molecules in a generic fashion thus providing an anchor site on the surface of the gel fibre to initiate drug crystal nucleation and growth. This technique potentially represents a route to growth of hard-to-nucleate polymorphic modifications. The co-gel comprising two components holding together by non-covalent ammonium-crown ether interaction can be easily switched back to the sol state by adding competitive binding cations.