Passive tumour targeting and extravasation of cylindrical polymer brushes in mouse xenografts. Issue 58 (29th March 2016)

• Record Type: Journal Article
• Authors: Müllner, Markus; Mehta, Dharmini; Nowell, Cameron J.; Porter, Christopher J. H.
• Is Part Of: Chemical communications. Volume 52:Issue 58(2016)
• Page Start: 9121
• Page End: 9124
• Publication Date: 2016-03-29
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc00447d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The passive tumour targeting and extravasation performance of PEGMA-based cylindrical polymer brushes was investigated, including their behaviour upon changes to their aspect ratio. Abstract : The shape-persistent nature and conformation of cylindrical polymer brushes (CPBs) present opportunities to explore the properties of anisotropic ( i.e. non spherical) nanomaterials in biological settings. This study shows that CPBs with lengths of up to 1 μm are able to passively target tumours via the enhanced permeation and retention (EPR) effect. Moreover, large CPBs with higher aspect ratios (ARs) were able to penetrate tumours with similar efficiencies to much smaller systems with lower ARs.