A facile and highly chemoselective synthesis of 1-thia-3a, 6-diaza-benzo[e]azulen-3-ones by 7-exo-dig/trig halocyclizations. Issue 103 (25th October 2016)

• Record Type: Journal Article
• Authors: Kuila, Bilash; Mahajan, Dinesh; Singh, Prabhpreet; Bhargava, Gaurav
• Is Part Of: RSC advances. Volume 6:Issue 103(2016)
• Page Start: 101587
• Page End: 101591
• Publication Date: 2016-10-25
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra23493c
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The manuscript describes a study on relatively unexplored halogen mediated 7- exo-dig / trig cyclization reactions of 2-(2-amino-aryl)-3-prop-2-ynyl/allyl-thiazolidin-4-ones for the formation of thiazole condensed 1, 4-benzodiazepines in good yields. Abstract : This manuscript describes a study on relatively unexplored halogen mediated 7- exo-dig / trig cyclization reactions of 2-(2-amino-aryl)-3-prop-2-ynyl/allyl-thiazolidin-4-ones for the formation of thiazole condensed 1, 4-benzodiazepines in good yields. The reactions are facile, chemoselective and involve the use of simple substrates leading to synthesis of diversely functionalized 1, 4-benzodiazepines. The synthesis of such condensed 1, 4-benzodiazepines is important in terms of their usefulness as biological active agents.