Kidney Allograft Fibrosis After Transplantation From Uncontrolled Circulatory Death Donors. Issue 2 (February 2015)

• Record Type: Journal Article
• Authors: Viglietti, Denis; Abboud, Imad; Hill, Gary; Vernerey, Dewi; Nochy, Dominique; Antoine, Corinne; Fieux, Fabienne; Assayag, Maureen; Verine, Jérôme; Gaudez, François; Loupy, Alexandre; Glotz, Denis; Lefaucheur, Carmen
• Is Part Of: Transplantation. Volume 99:Issue 2(2015)
• Publication Date: 2015-02
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; Transplantation immunology -- Periodicals; 617.95
• DOI: 10.1097/TP.0000000000000228
• Languages: English
• ISSNs: 0041-1337

Abstract

Abstract : Background: Existing data suggest that increased interstitial fibrosis may occur abnormally in renal transplants from donations after uncontrolled circulatory death (uDCD). Methods: To evaluate the factors that are associated with the progression of fibrosis and its functional impact on renal grafts, we compared 76 uDCD recipients with 86 recipients of kidney donations after brain death at 1-year after transplantation. Groups were matched for donor age, rank of transplantation, and absence of human leukocyte antigen sensitization. Histology was performed on sequential biopsies in uDCD recipients. Associations between variables were analyzed using linear mixed models and univariate analyses. Results: In the uDCD group, increased fibrosis was detected 3 months after transplantation compared to before implantation. After 1 year, interstitial fibrosis and tubular atrophy score was significantly greater (1.5 ± 0.7 vs. 1.0 ± 0.9; P = 0.003) and estimated glomerular filtration rate (49.5 ± 17.4 vs. 60.6 ± 19.1 mL/min/1.73 m 2 ; P = 0.0003) was significantly lower in the uDCD group than in the donations after brain death group. No flow duration and donor age were significantly associated with accelerated fibrosis. Interstitial fibrosis and tubular atrophy score, interstitial inflammation score, and estimated glomerular filtration rate were significantly worse in uDCD patients with no flow longer than 10 min. Conclusion: Donations after uncontrolled circulatory death grafts show more fibrosis after transplantation. No flow duration is associated with accelerated fibrosis and should be considered during uDCD graft allocation. Abstract : This study analyzes 1-year, posttransplant, pathological outcomes of uncontrolled circulatory death donor kidneys with respect to accelerated interstitial fibrosis, tubular atrophy, interstitial inflammation, and eGFR. Lack of blood flow for more than 10 minutes associates with worse outcomes. Supplemental digital content is available in the text.