Brief Report: Reduced Cell-Associated HTLV-2 DNA in Antiretroviral Treated HIV-1–HCV-Coinfected Patients Who Either Received Interferon-α/Ribavirin-Based Hepatitis C Therapy or Had Spontaneous HCV RNA Clearance. (1st July 2015)

• Record Type: Journal Article
• Authors: Abad-Fernández, María; Dronda, Fernando; Moreno, Ana; Casado, José Luis; Pérez-Elías, María-Jesús; Quereda, Carmen; Moreno, Santiago; Vallejo, Alejandro
• Is Part Of: Journal of acquired immune deficiency syndromes. Volume 69:Number 3(2015:Mar.)
• Publication Date: 2015-07-01
• Subjects: HTLV-2 infection -- HIV-1–HCV coinfection -- cell-associated HTLV-2 DNA -- immune activation -- IL-6 level; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome -- Periodicals; AIDS (Disease); Periodicals; 616.9792005
• DOI: 10.1097/QAI.0000000000000608
• Languages: English
• ISSNs: 1525-4135

Abstract

Abstract : Abstract: We analyzed the effect of interferon α (IFN-α) and ribavirin (RBV) therapy on cell-associated human T-lymphotropic virus type 2 (HTLV-2) DNA in HIV-1-coinfected patients receiving antiretroviral therapy. Sixty-one patients under suppressive antiretroviral therapy were included: 37 with hepatitis C virus (HCV) infection, 15 with sustained virologic response (N = 10), relapse (N = 2), or with nonresponse (N = 3) after IFN-α/RBV treatment, and 9 with spontaneous HCV RNA clearance. Patients who were treated with IFN-α/RBV or had spontaneous HCV clearance had lower level of cell-associated HTLV-2 DNA ( P = 0.022 and P = 0.040, respectively). Both IFN-alpha treatment and the ability to spontaneously clear HCV infection seem to reduce cell-associated HTLV-2 DNA in HIV-1-coinfected patients. Abstract : Supplemental Digital Content is Available in the Text.