OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF TYPE 3 NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION. Issue 11 (November 2015)

• Record Type: Journal Article
• Authors: Kuehlewein, Laura; Dansingani, Kunal K.; de Carlo, Talisa E.; Bonini Filho, Marco A.; Iafe, Nicholas A.; Lenis, Tamara L.; Freund, K. Bailey; Waheed, Nadia K.; Duker, Jay S.; Sadda, SriniVas R.; Sarraf, David
• Is Part Of: Retina. Volume 35:Issue 11(2015:Nov.)
• Publication Date: 2015-11
• Subjects: age-related macular degeneration -- angiography -- optical coherence tomography angiography; Retina -- Diseases -- Periodicals; Retinal Diseases; Vitreous Body; 617.735
• DOI: 10.1097/IAE.0000000000000835
• Languages: English
• ISSNs: 0275-004X

Abstract

Abstract : Purpose: To characterize the vascular structure of Type 3 neovascularization secondary to age-related macular degeneration using optical coherence tomography angiography. Methods: Optical coherence tomography angiography cube scans (3 mm × 3 mm) were acquired in 29 eyes of 24 patients with Type 3 lesions secondary to age-related macular degeneration using the RTVue XR Avanti with AngioVue, Split-spectrum amplitude-decorrelation, and motion correction technology. Automated layer segmentation boundaries were adjusted to best visualize the neovascular complex on en face projection images. Results: A distinct neovascular complex could be identified in 10 (34%) eyes, all of which were active on optical coherence tomography imaging. In all 10 eyes, the neovascular complex appeared as a small tuft of bright, high-flow tiny vessels with curvilinear morphology located in the outer retinal layers with a feeder vessel communicating with the inner retinal circulation (i.e., deep retinal capillary plexus). The mean (SD) size of the neovascular complex measured 0.07 (± 0.07) mm 2 . Conclusion: With optical coherence tomography angiography, it is possible to identify small intraretinal neovascular complexes communicating with the deep retinal capillary plexus in eyes with Type 3 neovascularization secondary to age-related macular degeneration. Qualitative and quantitative analyses of Type 3 neovascular complexes can be performed using optical coherence tomography angiography. Abstract : A neovascular complex in 10 of 29 eyes with Type 3 neovascularization secondary to age-related macular degeneration was identified. It appeared as a small tuft of bright, high-flow tiny vessels with curvilinear morphology located in the outer retinal layers with a feeder vessel communicating with the inner retinal circulation.