Association of Hippocampal Magnetic Resonance Imaging With Learning and Memory Deficits in HIV-1–Seropositive Patients. (1st December 2015)

• Record Type: Journal Article
• Authors: Wang, Man; Wang, Qi; Ding, Haibo; Shang, Hong
• Is Part Of: Journal of acquired immune deficiency syndromes. Volume 70:Number 4(2015)
• Publication Date: 2015-12-01
• Subjects: hippocampus -- HIV-1 -- association -- cognitive impairment -- MRI; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome -- Periodicals; AIDS (Disease); Periodicals; 616.9792005
• DOI: 10.1097/QAI.0000000000000789
• Languages: English
• ISSNs: 1525-4135

Abstract

Abstract : Objective: To investigate the relationship between cognitive impairment and hippocampal morphological and functional changes in HIV-seropositive patients. Methods: Thirty HIV+ patients who complain of memory decrease and 15 healthy volunteers were recruited. Performances of learning and memory were assessed using Hopkins Verbal Learning Test-Revised (HVLT-R) and Brief Visuospatial Memory Test-Revised (BVMT-R). Bilateral hippocampal volume, apparent diffusion coefficient (ADC) value, fractional anisotropy value, and magnetic resonance spectroscopy variables of bilateral hippocampus and parahippocampal gyrus were detected by 3.0 T magnetic resonance scanner. Results: We found significant differences in all cognitive outcomes but one between HIV+ and HIV− patients. There was a difference in the ADC value of left parahippocampal gyrus between mild-impairment group and severe-impairment group ( P = 0.018). We found differences in the choline (Cho), Cho/creatinine (Cr), and N -acetylaspartate/Cr of left hippocampus ( P = 0.002, P = 0.008, P = 0.002) and the Cho/Cr of right parahippocampal gyrus ( P = 0.023) between HIV+ and HIV− patients and in the myoinositol of left hippocampus ( P = 0.003) and the glutamate and glutamine of right hippocampus ( P < 0.001) between mild-impairment group and severe-impairment group. We found significant positive correlations between N -acetylaspartate/Cr of left hippocampus and outcomes of HVLT-R and BVMT-R. There were significant negative correlations between ADC values of hippocampus and parahippocampal gyrus and outcomes of HVLT-R and BVMT-R and between Cho and Cho/Cr of hippocampus and parahippocampal gyrus and outcomes of HVLT-R and BVMT-R. Conclusions: The performance of verbal learning and visual memory was significantly decreased in HIV-1–seropositive patients. The cognitive impairment of HIV infection was associated with conductive function and metabolic changes of hippocampus and parahippocampal gyrus in this study. Abstract : Supplemental Digital Content Is Available in the Text.