Brief Report: Consequences of Presentation With Advanced HIV Disease in Pregnancy. (1st December 2015)

• Record Type: Journal Article
• Authors: Floridia, Marco; Tamburrini, Enrica; Masuelli, Giulia; Guaraldi, Giovanni; Molinari, Atim; Cetin, Irene; Dalzero, Serena; Spinillo, Arsenio; Liuzzi, Giuseppina; Pinnetti, Carmela; Vicini, Ilaria; Castelli, Paula; Sacchi, Valentina; Ravizza, Marina
• Is Part Of: Journal of acquired immune deficiency syndromes. Volume 70:Number 4(2015)
• Publication Date: 2015-12-01
• Subjects: HIV -- pregnancy -- advanced HIV disease -- HIV vertical transmission -- African provenance; AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome -- Periodicals; AIDS (Disease); Periodicals; 616.9792005
• DOI: 10.1097/QAI.0000000000000791
• Languages: English
• ISSNs: 1525-4135

Abstract

Abstract : Abstract: Among 469 women with a diagnosis of HIV in pregnancy, 74 (15.8%) presented with less than 200 CD4 cells per cubic millimeter. The only variable significantly associated with this occurrence was African origin (odds ratio: 2.22, 95% confidence intervals: 1.32 to 3.75, P = 0.003). Four women with low CD4 (5.6%), compared with none with higher CD4 counts, had severe AIDS-defining conditions ( P < 0.001) during pregnancy or soon after delivery, and one transmitted HIV to the newborn. Early preterm delivery (<32 weeks) was significantly more frequent with low CD4 (6.2% vs. 1.4%, P = 0.015). An earlier access to HIV testing, particularly among immigrants of African origin, can prevent severe HIV-related morbidity.