Cranioplasty Using a Novel Osteoconductive Scaffold and Platelet Gel. (March 2016)

• Record Type: Journal Article
• Authors: Tseng, Ching-Li; Chang, Guang-Wei; OU, Kuang-Ling; Chou, Wei-Ting; Wu, Te-Hsing; Fang, Hsu-Wei; Tsai, Jui-Che; Chen, Tim-Mo
• Is Part Of: Annals of plastic surgery. Volume 76(2016:May)Supplement 1
• Publication Date: 2016-03
• Subjects: acrylic acid -- calvarial bone defect -- platelet fibrin glue -- N-isopropylacrylamide; Surgery, Plastic -- Periodicals; 617.95205
• DOI: 10.1097/SAP.0000000000000696
• Languages: English
• ISSNs: 0148-7043

Abstract

Abstract : Background: Commonly used materials for cranioplasty include autogenous bone grafts, methyl methacrylate, and titanium mesh. We evaluated a novel osteoconductive scaffold [ N -isopropylacrylamide cross-linked with acrylic acid using γ-rays (ANa powder)] mixed with platelet gel for cranioplasty. Methods: ANa powder mixed with platelet gel was implanted into a 15 × 15-mm, full-thickness calvarial bone defect in 5 New Zealand white rabbits. ANa powder mixed with phosphate-buffered saline was implanted in 5 rabbits. The calvarial bone defect was left unreconstructed in another 5 rabbits. Twelve weeks after surgery, computed tomography examination was used to evaluate the radiographic evidence of bone healing in vivo. Bone specimens were then retrieved for histologic study. Results: The ANa scaffold mixed with platelet gel is biocompatible, biodegradable, and both osteoconductive and osteoinductive, leading to progressive growth of new bone into the calvarial bone defect. Conclusion: The use of this novel osteoconductive scaffold combined with osteoinductive platelet gel offers a valuable alternative for the reconstruction of calvarial bone defects.