Noncarboplatin-induced Sensorineural Hearing Loss in a Patient With an Intracranial Nongerminomatous Germ Cell Tumor. Issue 4 (May 2016)

• Record Type: Journal Article
• Authors: Vitanza, Nicholas A.; Shaw, Theresa M.; Gardner, Sharon L.; Allen, Jeffrey C.; Harter, David H.; Karajannis, Matthias A.
• Is Part Of: Journal of pediatric hematology/oncology. Volume 38:Issue 4(2016)
• Publication Date: 2016-05
• Subjects: intracranial nongerminomatous germ cell tumor -- sensorineural hearing loss -- carboplatin -- ototoxicity; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0b013e318287310e
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : Treatment for intracranial germ cell tumors includes platinum-based chemotherapy and external beam radiation therapy, which are risk factors for hearing loss. In patients who experience significant sensorineural ototoxicity due to cochlear hair cell injury, dose reduction of chemotherapy may be necessary. This report describes an adolescent male, with excellent treatment response for an intracranial nongerminomatous germ cell tumor, who developed sensorineural hearing loss, which was central rather than cochlear in origin and unrelated to carboplatin. This patient highlights the need to carefully differentiate the type and etiology of sensorineural hearing loss in patients with brain tumors receiving ototoxic chemotherapy.