Comprehensive Review on Colorectal Cancer and Transplant. Issue 11 (4th October 2017)

• Record Type: Journal Article
• Authors: Prenner, S.; Levitsky, J.
• Is Part Of: American journal of transplantation. Volume 17:Issue 11(2017)
• Page Start: 2761
• Page End: 2774
• Publication Date: 2017-10-04
• Subjects: clinical research/practice -- organ transplantation in general -- hematology/oncology -- cancer/malignancy/neoplasia: risk factors -- complication: malignant; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ajt.14340
• Languages: English
• ISSNs: 1600-6135

Abstract

Abstract : Colorectal cancer (CRC) is a common malignancy worldwide. Some studies suggest that organ recipients are at a higher risk for CRC than the general population. The underlying transplant indications and their inherent risk factors for CRC may drive the variation in incidence rates that are seen in patients receiving different allografts. Recipients with cystic fibrosis are now recognized as a population at high risk for CRC at a young age. Transplant recipients have high mortality following a CRC diagnosis, even if it is detected at an early stage. Certain types of immunosuppression have been shown to accelerate cancer transformation and may contribute to the more aggressive phenotype seen in organ recipients. Given the high incidence and progressive nature of posttransplant CRC, shorter screening intervals with a modality that can detect early‐stage polyps may be essential to prevent mortality. Future research is needed to better elucidate the role of immunosuppression in carcinogenesis. This comprehensive review examines CRC risk, screening, and management specific to organ transplant candidates and recipients. Abstract : This review presents the existing knowledge of colorectal cancer risk and screening, as well as management recommendations specific to solid organ transplant candidates and recipients.