Localization of Radiolabeled Somatostatin Analogs in the Spleen. (February 2016)

• Record Type: Journal Article
• Authors: Melis, Marleen; Kaemmerer, Daniel; de Swart, Jan; Kulkarni, Harshad R.; Lupp, Amelie; Sänger, Jörg; Groen, Harald C.; Konijnenberg, Mark W.; de Jong, Marion; Baum, Richard P.
• Is Part Of: Clinical nuclear medicine. Volume 41:Number 2(2016)
• Publication Date: 2016-02
• Subjects: spleen -- radiolabeled somatostatin analogs -- SSTR -- autoradiography -- immunohistochemistry; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000001026
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: Radiolabeled somatostatin (SST) analogs, used to visualize and treat SST receptor (SSTR)–expressing neuroendocrine tumors, also accumulate in the spleen. There is a high interpatient variation and no significant radiation-induced splenic toxicity; however, an absorbed dose-related reduction in spleen size was detected. However, the exact localization of radioactivity and the role of SST receptors in splenic retention are unknown. Therefore, we performed ex vivo micro-SPECT of the isolated spleen from a patient with a pancreatic neoplasm after 1 GBq (27 mCi) 177 Lu-DOTATATE administration, followed by autoradiography and immunohistochemistry. Ex vivo autoradiography demonstrated convincingly that most radioactivity accumulated in red pulp.