Absorption and excretion of Tetrabromobisphenol A in male Wistar rats following subchronic dermal exposure. (March 2016)

• Record Type: Journal Article
• Authors: Yu, Yunjiang; Xiang, Mingdeng; Gao, Dandan; Ye, Hao; Wang, Qiong; Zhang, Yanping; Li, Liangzhong; Li, Hui
• Is Part Of: Chemosphere. Volume 146(2016)
• Page Start: 189
• Page End: 194
• Publication Date: 2016-03
• Subjects: Tetrabromobisphenol A -- Absorption -- Urinary and fecal excretion -- Dermal exposure; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2015.12.027
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: Tetrabromobisphenol A (TBBPA) is widely used as a flame retardant and frequently detected in environmental and biological samples. In this study, male Wistar rats were repeatedly exposed by dermal application to 20, 60, 200 and 600 mg TBBPA/kg body weight during 90 days. Concentrations of TBBPA in serum, urine and feces after dermal exposure were determined. TBBPA concentrations in serum ranged from 19.04 to 427.20 g/g lipids. The percentage of TBBPA dose recovered in serum on the 90th day varied from 0.002 ± 0.002% to 0.013 ± 0.008%, and the percentage of dose excreted in urine varied from 0.004 ± 0.002% to 0.072 ± 0.027%, while the percentage of dose recovered in feces were 3.30 ± 0.61% to 11.13 ± 3.16%. The results showed that about 3.31–11.21% TBBPA was absorbed dermally under different dosing regimens. TBBPA was excreted mainly in feces and small only amounts were recovered in urine. Highlights: TBBPA in serum, urine and feces after subchronic dermal exposure were determined. About 3.31–11.21% TBBPA was absorbed dermally under different dosing regimens. The majority of TBBPA was excreted in feces, but the minority in urine.