Long term correlation of subthalamic beta band activity with motor impairment in patients with Parkinson's disease. Issue 11 (November 2017)

• Record Type: Journal Article
• Authors: Neumann, Wolf-Julian; Staub-Bartelt, Franziska; Horn, Andreas; Schanda, Julia; Schneider, Gerd-Helge; Brown, Peter; Kühn, Andrea A.
• Is Part Of: Clinical neurophysiology. Volume 128:Issue 11(2017:Nov.)
• Page Start: 2286
• Page End: 2291
• Publication Date: 2017-11
• Subjects: Deep brain stimulation -- Basal ganglia -- Local field potentials -- Beta oscillations -- Subthalamic nucleus; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2017.08.028
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Subthalamic beta activity was recorded with an implantable DBS pulse generator over 8 months in 12 patients with Parkinson's disease. Dopaminergic medication suppresses subthalamic beta activity at operation, 3 and 8 months after DBS. Beta activity correlates with parkinsonian symptom severity over time. Abstract: Objectives: To investigate the long term association of subthalamic beta activity with parkinsonian motor signs. Methods: We recruited 15 patients with Parkinson's disease undergoing subthalamic DBS for local field potential recordings after electrode implantation, and at 3 and 8 months post-operatively using the implantable sensing enabled Activa PC + S (Medtronic). Three patients dropped out leaving 12 patients. Recordings were conducted ON and OFF levodopa at rest. Beta (13–35 Hz) peak amplitudes were extracted, compared across time points and correlated with UPDRS-III hemibody scores. Results: Peaks in the beta frequency band (13–35 Hz) in the OFF medication state were found in all hemispheres. Mean beta activity was significantly suppressed by levodopa at all recorded time points ( P < 0.007) and individual beta power amplitude correlated with parkinsonian motor impairment across time points and dopaminergic states (pooled data; ρ = 0.25, P < 0.001). Conclusions: Our results indicate that beta-activity is correlated with parkinsonian motor signs over a time period of 8 months. Significance: Beta-activity may be a chronically detectable biomarker of symptom severity in PD that should be further evaluated under ongoing DBS.