Adiposity phenotypes are associated with type-2 diabetes: LAP index, body adiposity index, and neck circumference. (November 2017)

• Record Type: Journal Article
• Authors: Marcadenti, Aline; Fuchs, Flavio D.; Moreira, Leila B.; Gus, Miguel; Fuchs, Sandra C.
• Is Part Of: Atherosclerosis. Volume 266(2017)
• Page Start: 145
• Page End: 150
• Publication Date: 2017-11
• Subjects: Diabetes mellitus -- Hypertension -- Abdominal obesity -- Waist circumference -- Lipid accumulation product -- Body adiposity index -- Neck circumference; Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2017.09.022
• Languages: English
• ISSNs: 0021-9150

Abstract

Abstract: Background and aims: Adiposity phenotypes can be detected by anthropometric indexes associated with type-2 diabetes mellitus (T2DM). Besides body mass index (BMI) and waist circumference (WC), new indices seem to be able to identify T2DM. This study aimed to evaluate independent associations of T2DM with lipid accumulation product (LAP index), neck circumference (NC) and body adiposity index (BAI) in patients with hypertension. Methods: A cross-sectional study was carried out among 430 patients with hypertension. The T2DM diagnosed was standardized. WC and NC (cm) were measured and BMI was calculated. LAP index was calculated separately for men [(WC-65) × TG] and women [(WC-58) × TG]; BAI was evaluated in percentiles according to hip (cm)/[height (m) 1.5 ]-18. Results: Participants were aged 58.3 ± 11.7 years, had systolic blood pressure (SBP) 154.2 ± 24.9 mmHg, diastolic blood pressure (DBP) 89.0 ± 14.7 mmHg, and BMI 30.1 ± 6.0 kg/m 2 . There was 145 men and 285 women, and 142 participants had T2DM. Analyses carried out separately by gender showed that among men, BAI at the 75th percentile increased about 60% the risk of T2DM, while among women, those in the upper quartile of LAP and NC had increased risk of T2DM (prevalence ratio (PR): 2.93; 95%CI: 1.62–5.28 and 3.30; 95%IC: 1.78–6.14, respectively), after adjustment for potential confounders. Conclusions: Adiposity phenotypes such as LAP index and neck circumference were independently associated with T2DM in hypertensive women, and BAI was associated with T2DM in men. Graphical abstract: Highlights: This study showed a positive association of LAP and neck circumference with type-2 diabetes mellitus among women. Among men, there was an association between BAI and type-2 diabetes mellitus. LAP, BAI and neck circumference can contribute to trace type-2 diabetes mellitus-associated adiposity phenotypes.