Comparison of CHA2DS2-VASc, CHADS2 and HATCH scores for the prediction of new-onset atrial fibrillation in cancer patients: A nationwide cohort study of 760, 339 study participants with competing risk analysis. (November 2017)

• Record Type: Journal Article
• Authors: Hu, Wei-Syun; Lin, Cheng-Li
• Is Part Of: Atherosclerosis. Volume 266(2017)
• Page Start: 205
• Page End: 211
• Publication Date: 2017-11
• Subjects: Atrial fibrillation -- Cancer -- CHA2DS2-VASc score -- CHADS2 score -- HATCH score; Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2017.10.007
• Languages: English
• ISSNs: 0021-9150

Abstract

Abstract: Background and aims: The current study was conducted to assess the ability of CHA2 DS2 -VASc, CHADS2 and HATCH scores in predicting new-onset atrial fibrillation (AF) among patients with cancer. Methods: Patients with newly diagnosed cancer between 1 January, 2000 and 31 December, 2011, from the Registry for Catastrophic Illness Patient Database, were defined as the study cohort. CHA2 DS2 -VASc, CHADS2 and HATCH scores were used for new-onset AF prediction in these study patients, and the predictive accuracy of the scores was assessed by the receiver operating characteristics (ROC) curve. Results: A total of 760, 339 cancer patients were identified as the study participants. The ROC curves were 0.68 (95% confidence interval [CI] = 0.68–0.69) for the CHA2 DS2 -VASc score, 0.67 (95% CI = 0.67–0.68) for the CHADS2 score and 0.69 (95% CI = 0.69–0.70) for the HATCH score. There were significant differences of c-statistics among CHA2 DS2 -VASc score, CHADS2 score and HATCH score (CHA2 DS2 -VASc score vs. CHADS2 score, p = 0.01; CHA2 DS2 -VASc score vs. HATCH score, p = 0.002; CHADS2 score vs. HATCH score, p < 0.001). Conclusions: The current study is the first to assess the prognostic value of 3 AF risk scores (CHA2 DS2 -VASc, CHADS2 and HATCH scores) in patients with newly-diagnosed cancer. HATCH score was found to have a slightly but significantly better predictive performance than the other 2 scores. Highlights: The current study is the first to compare the predictive value of three previously established scores in risk stratification for new-onset AF in cancer patients. HATCH score was found to have a slightly but significantly better discrimination ability than CHA2 DS2 -VASc and CHADS2 scores. The present study is a nationwide cohort study with 760339 study participants.