Synthesis and evaluation of a novel molecularly imprinted polymer for the selective isolation of acetylsalicylic acid from aqueous solutions. Issue 4 (December 2016)

• Record Type: Journal Article
• Authors: Meischl, Florian; Schemeth, Dieter; Harder, Matthias; Köpfle, Norbert; Tessadri, Richard; Rainer, Matthias
• Is Part Of: Journal of environmental chemical engineering. Volume 4:Issue 4(2016:Dec.)Part A
• Page Start: 4083
• Page End: 4090
• Publication Date: 2016-12
• Subjects: AA acrylamide -- ACN acetonitrile -- AIBN azobisisobutyronitrile -- ASA acetylsalicylic acid -- COX cyclooxygenase -- DAD diode array detector -- DCM dichloromethane -- EGDMA ethylene glycol dimethacrylate -- EtOH ethanol -- HOAc acetic acid -- HPLC high performance liquid chromatography -- MeOH methanol -- MIP molecularly imprinted polymer -- MISPE molecularly imprinted solid-phase extraction -- NIP non-imprinted polymer -- NSAIDs non-steroidal anti-inflammatory drugs -- SEM scanning electron microscopy -- SPE solid-phase extraction -- TFA trifluoroacetic acid -- UV ultraviolet; Molecularly imprinted polymer -- Acetylsalicylic acid -- Pharmaceuticals removal -- Water treatment; Chemical engineering -- Environmental aspects -- Periodicals; Environmental engineering -- Periodicals; Chemical engineering -- Environmental aspects; Environmental engineering; Periodicals; 660.0286
• DOI: 10.1016/j.jece.2016.09.013
• Languages: English
• ISSNs: 2213-2929

Abstract

Graphical abstract: Highlights: Enhanced synthesis of MIP for selective ASS recognition. High binding capacities under acidic conditions. High removal factors and recoveries in comparison to NIP. Removal of ASS from river water samples. Abstract: This study reports a new molecularly imprinted polymer (MIP) for selective recognition to acetylsalicylic acid (ASA) by a non-covalent imprinting process. ASA being part of the non-steroidal anti-inflammatory drugs (NSAIDs) is also known as aspirin. Due to human excretion of the drug and its metabolites, persistent environmental contamination of ASA occurs. This requires highly efficient sorbents which permit the isolation of such pharmaceuticals from wastewater. In this regard, we synthesized a MIP by a simple thermal bulk polymerization method using acrylamide (AA) as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the crosslinker. In order to determine the binding capacity of the new polymer several adsorption studies using different solvents were performed. Fitting of the data points with a Langmuir isotherm revealed a maximum adsorption capacity of 328.6 mg g −1 polymer in water at pH 3. It was observed that the present MIP allowed the simultaneous isolation of ASA and salicylic acid (SA), its major metabolite. This is a main advantage as both, ASA and SA can be isolated in a single extraction step. In a further experiment, the adsorption performance of the imprinted polymer was evaluated and compared to the non-imprinted polymer (NIP) and provided higher capacity values for the MIP. To check the ability of reusability, the polymer was loaded with standard solutions for several times and the percentage of removal was calculated after each treatment. Finally, the applicability of the polymer for the isolation of ASA was investigated for river water as a more complex sample.