A simple synthesis of benzofurans by acid-catalyzed domino reaction of salicyl alcohols with N-tosylfurfurylamine. Issue 46 (16th November 2017) - Merkushev, Anton A.
Abstract: A simple route to polysubstituted benzofurans based on the domino reaction of commercial or easily available salicyl alcohols with N -protected furfurylamine has been designed and developed. The reaction was found to proceed with reasonable yields under heating of substrates in acetic acid in the presence of catalytic amount of conc. HCl when tosyl was used as protecting group. Graphical abstract: