Effect of ultra-low-dose estradiol and dydrogesterone on arterial stiffness in postmenopausal women. (April 2014)

• Record Type: Journal Article
• Authors: Matsui, S.; Yasui, T.; Tani, A.; Kato, T.; Uemura, H.; Kuwahara, A.; Matsuzaki, T.; Arisawa, K.; Irahara, M.
• Is Part Of: Climacteric. Volume 17:Number 2(2014:Apr.)
• Page Start: 191
• Page End: 196
• Publication Date: 2014-04
• Subjects: PULSE WAVE VELOCITY -- ULTRA-LOW-DOSE ESTRADIOL -- ARTERIAL STIFFNESS; Menopause -- Periodicals; Menopause -- Hormone therapy -- Periodicals; Menopause -- Periodicals; Estrogen Replacement Therapy -- Periodicals; Gynecology -- Periodicals; Societies, Medical -- Periodicals; 612.665
• DOI: 10.3109/13697137.2013.856399
• Languages: English
• ISSNs: 1369-7137

Abstract

Abstract: Background Ultra-low-dose estradiol is known to improve menopausal symptoms and increase bone mineral density. However, the effect of ultra-low-dose estradiol on vascular function has not been clarified. Objectives We examined the effects of ultra-low-dose estradiol on brachial-ankle pulse wave velocity (baPWV) and circulating markers of cardiovascular risk. Patients and methods Twenty-eight postmenopausal women were enrolled in this study. Fourteen women received oral estradiol (0.5 mg) and dydrogesterone (5 mg) every day for 12 months (ultra-low-dose group) as hormone replacement therapy (HRT) and 14 women as a control group did not receive HRT. The baPWV, lipid profiles, homeostasis model assessment of insulin resistance (HOMA-IR) and vascular inflammatory markers were measured. Results The baPWV level significantly decreased in the ultra-low-dose group ( p = 0.037), while the baPWV level did not significantly change in the control group. HOMA-IR tended to decrease in the ultra-low-dose group ( p = 0.076). Systolic blood pressure and diastolic blood pressure did not change significantly in either group. Conclusion An HRT regimen using oral ultra-low-dose estradiol and dydrogesterone has an effect on arterial stiffness and insulin resistance.