Autoantibodies in juvenile-onset myositis: Their diagnostic value and associated clinical phenotype in a large UK cohort. (November 2017)

• Record Type: Journal Article
• Authors: Tansley, Sarah L.; Simou, Stefania; Shaddick, Gavin; Betteridge, Zoe E.; Almeida, Beverley; Gunawardena, Harsha; Thomson, Wendy; Beresford, Michael W.; Midgley, Angela; Muntoni, Francesco; Wedderburn, Lucy R.; McHugh, Neil J.
• Is Part Of: Journal of autoimmunity. Volume 84(2017)
• Page Start: 55
• Page End: 64
• Publication Date: 2017-11
• Subjects: Myositis -- Paediatric rheumatology -- Autoantibody -- Phenotype -- Autoimmune disease -- Myopathy; Autoimmunity -- Periodicals; Autoimmune diseases -- Periodicals; Autoantibodies -- Periodicals; Autoimmune Diseases -- Periodicals; Auto-immunité -- Périodiques; Maladies auto-immunes -- Périodiques; Electronic journals; 616.978005
• DOI: 10.1016/j.jaut.2017.06.007
• Languages: English
• ISSNs: 0896-8411

Abstract

Abstract: Objectives: Juvenile myositis is a rare and heterogeneous disease. Diagnosis is often difficult but early treatment is important in reducing the risk of associated morbidity and poor outcomes. Myositis specific autoantibodies have been described in both juvenile and adult patients with myositis and can be helpful in dividing patients into clinically homogenous groups. We aimed to explore the utility of myositis specific autoantibodies as diagnostic and prognostic biomarkers in patients with juvenile-onset disease. Methods: Using radio-labelled immunoprecipitation and previously validated ELISAs we examined the presence of myositis specific autoantibodies in 380 patients with juvenile-onset myositis in addition to, 318 patients with juvenile idiopathic arthritis, 21 patients with juvenile-onset SLE, 27 patients with muscular dystrophies, and 48 healthy children. Results: An autoantibody was identified in 60% of juvenile-onset myositis patients. Myositis specific autoantibodies (49% patients) were exclusively found in patients with myositis and with the exception of one case were mutually exclusive and not found in conjunction with another autoantibody. Autoantibody subtypes were associated with age at disease onset, key clinical disease features and treatment received. Conclusions: In juvenile patients the identification of a myositis specific autoantibody is highly suggestive of myositis. Autoantibodies can be identified in the majority of affected children and provide useful prognostic information. There is evidence of a differential treatment approach and patients with anti-TIF1γ autoantibodies are significantly more likely to receive aggressive treatment with IV cyclophosphamide and/or biologic drugs, clear trends are also visible in other autoantibody subgroups. Highlights: Using immunoprecipitation, an autoantibody is identifiable in most children with juvenile-onset myositis. Myositis specific autoantibodies are highly specific and were not identified in control groups. Autoantibodies identify patient subgroups associated with clinically important disease features. Evidence of an existing differential treatment approach between autoantibody subgroups is presented.