Biosynthesis of leukotriene B4. (October 2017)

• Record Type: Journal Article
• Authors: Wan, Min; Tang, Xiao; Stsiapanava, Alena; Haeggström, Jesper Z.
• Is Part Of: Seminars in immunology. Volume 33(2017)
• Page Start: 3
• Page End: 15
• Publication Date: 2017-10
• Subjects: Leukotriene B4 (LTB4) -- Arachidonic acid (AA) -- 5-Lipoxygenase (5-LOX) -- 5-Lipoxygenase-activating protein (FLAP) -- LTA4 hydrolase (LTA4H); Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Immunity -- Periodicals; Immunologie -- Périodiques; Electronic journals; 616.079
• DOI: 10.1016/j.smim.2017.07.012
• Languages: English
• ISSNs: 1044-5323

Abstract

Abstract: Leukotriene B4 (LTB4 ) is a lipid mediator derived from arachidonic acid (AA) by the sequential action of 5-lipoxygenase (5-LOX), 5-lipoxygenase-activating protein (FLAP) and LTA4 hydrolase (LTA4 H). It was initially recognized for its involvement in the recruitment of neutrophils and is one of the most potent chemotactic agents known to date. A large body of data has indicated that LTB4 plays a significant role in many chronic inflammatory diseases, such as arthritis, chronic obstructive pulmonary disease (COPD), cardiovascular disease, cancer and more recently, metabolic disorder. In this review, we focus on the biosynthesis of LTB4 and its biological effects. In particular, we will describe a basic biochemical understanding integrated with recent developments in the field of structural biology of the three key enzymes (5-LOX, FLAP and LTA4 H) in LTB4 biosynthesis, and also summarize the most outstanding work on in vivo biological and pathogenic roles of these enzymes and the development of enzyme inhibitors.