DIAGNOSIS OF ENDOCRINE DISEASE: Endocrine late-effects of childhood cancer and its treatments. Issue 4 (April 2017)

• Record Type: Journal Article
• Authors: Chemaitilly, Wassim; Cohen, Laurie E
• Is Part Of: European journal of endocrinology. Volume 176:Issue 4(2017)
• Page Start: R183
• Page End: R203
• Publication Date: 2017-04
• Subjects: Endocrinology -- Periodicals; 616.4005
• DOI: 10.1530/EJE-17-0054
• Languages: English
• ISSNs: 0804-4643

Abstract

Abstract : Endocrine complications are frequently observed in childhood cancer survivors (CCS). One of two CCS will experience at least one endocrine complication during the course of his/her lifespan, most commonly as a late-effect of cancer treatments, especially radiotherapy and alkylating agent chemotherapy. Endocrine late-effects include impairments of the hypothalamus/pituitary, thyroid and gonads, as well as decreased bone mineral density and metabolic derangements leading to obesity and/or diabetes mellitus. A systematic approach where CCS are screened for endocrine late-effects based on their cancer history and treatment exposures may improve health outcomes by allowing the early diagnosis and treatment of these complications.