Lipid remodelling in neuroendocrine secretion. (18th October 2017)

• Record Type: Journal Article
• Authors: Gasman, Stéphane; Vitale, Nicolas
• Is Part Of: Biology of the cell. Volume 109:Number 11(2017)
• Page Start: 381
• Page End: 390
• Publication Date: 2017-10-18
• Subjects: Endocytosis/exocytosis -- Inositol phosphates/phosphoinositides -- Lipid mediators -- Other endocrine glands -- Phospholipases; Cytology -- Periodicals; Electron microscopy -- Periodicals; 571.6
• DOI: 10.1111/boc.201700030
• Languages: English
• ISSNs: 0248-4900

Abstract

Abstract: Neuroendocrine cells secrete hormones and polypeptides through a complex membrane trafficking process that involves the transport of specific organelles, called large dense core secretory granules, from the Golgi apparatus to specialised sites at the plasma membrane where these vesicles are successively exocytosed and recaptured by endocytosis through tightly coupled reactions. The minimal machinery required for exocytosis has been defined as SNARE proteins associated with few accessory proteins. On the other side, clathrin and dynamin constitute major components of some of the most important endocytotic pathways. Although many protein contributors of both exocytosis and endocytosis are now identified, their actual interplay is not well resolved. Furthermore, the necessary tight coupling of exocytosis and compensatory endocytosis to maintain membrane homeostasis in neuroendocrine cells is far from being understood. In this review, we focus on the more recently identified role of lipids in these important processes that are above all membrane remodelling events. Abstract : Review : After docking and priming, secretory vesicles fuse with the plasma membrane to allow release of the vesicle content. To maintain cellular and membrane homeostasis, fused vesicular membranes (lipids and proteins) are selectively recaptured by a process called compensatory endocytosis. These different steps of the exo‐endocytosis cycle involve membrane remodelling and fine lipid dynamics, which will be detailed in this review.