Roles of ST2, IL‐33 and BNP in predicting major adverse cardiovascular events in acute myocardial infarction after percutaneous coronary intervention. Issue 11 (17th June 2017)

• Record Type: Journal Article
• Authors: Wang, Yan‐Peng; Wang, Jian‐Hua; Wang, Xiao‐Long; Liu, Jun‐Yi; Jiang, Fang‐Yun; Huang, Xiao‐Li; Hang, Jing‐Yu; Qin, Wei; Ma, Shi‐Xin; Zhang, Jie; Yuan, Min‐Jie; Li, Jing‐Bo; Lu, Zhi‐Gang; Wei, Meng
• Is Part Of: Journal of cellular and molecular medicine. Volume 21:Issue 11(2017)
• Page Start: 2677
• Page End: 2684
• Publication Date: 2017-06-17
• Subjects: ST2 -- IL‐33 -- BNP -- Major adverse cardiovascular events -- Acute myocardial infarction -- Percutaneous coronary intervention; Cytology; Medicine; Molecular Biology; Cytologie -- Périodiques; Médecine -- Périodiques; Biologie moléculaire -- Périodiques; Cytology -- Periodicals; Medicine -- Periodicals; Molecular biology -- Periodicals; 611.01805
• DOI: 10.1111/jcmm.13183
• Languages: English
• ISSNs: 1582-1838

Abstract

Abstract: This study investigated roles of serum ST2, IL‐33 and BNP in predicting major adverse cardiovascular events (MACEs) in acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Blood samples were collected from the included AMI patients ( n = 180) who underwent PCI. All patients were divided into the MACEs and MACEs‐free groups. Enzyme‐linked immunosorbent assay was performed to measure serum levels of ST2, IL‐33 and BNP. Severity of coronary artery lesion was evaluated by Gensini score. Pearson correlation analysis was used. A receiver operating characteristics curve was drawn to evaluate the potential roles of ST2, IL‐33 and BNP in predicting MACEs, and Kaplan–Meier curve to analyse the 1‐year overall survival rate. Logistic regression analysis was conducted to analyse the independent risk factors for MACEs. Compared with the MACEs‐free group, the serum levels of ST2, IL‐33 and BNP were significantly higher in the MACEs group. Serum levels of ST2, IL‐33 and BNP were positively correlated with each other and positively correlated with Gensini score. The area under curves of ST2, IL‐33 and BNP, respectively, were 0.872, 0.675 and 0.902. The relative sensitivity and specificity were, respectively, 76.27% and 85.92%, 69.49% and 58.68%, as well as, 96.61% and 77.69%. Serum levels of ST2, IL‐33 and BNP were independent risk factors for MACEs. The 1‐year overall survival rate was higher in AMI patients with lower serum levels of ST2, IL‐33 and BNP. In conclusion, serum levels of ST2, IL‐33 and BNP have potential value in predicting MACEs in AMI patients undergoing PCI.