Circulating Normal IgG as Stimulator of Regulatory T Cells: Lessons from Intravenous Immunoglobulin. Issue 11 (November 2017)

• Record Type: Journal Article
• Authors: Maddur, Mohan S; Kaveri, Srini V.; Bayry, Jagadeesh
• Is Part Of: Trends in immunology. Volume 38:Issue 11(2017)
• Page Start: 789
• Page End: 792
• Publication Date: 2017-11
• Subjects: intravenous immunoglobulin -- regulatory T cells -- antibody -- prostaglandin E2 -- dendritic cells -- IL-33 -- tregitopes -- DC-SIGN -- DCIR; Immunology -- Periodicals; 571.96
• DOI: 10.1016/j.it.2017.08.008
• Languages: English
• ISSNs: 1471-4906

Abstract

Abstract : Intravenous immunoglobulin (IVIG), a pooled normal IgG formulation prepared from thousands of healthy donors' plasma, is extensively used for the immunotherapy of autoimmune and inflammatory disorders. Recent reports demonstrate that IVIG exerts anti-inflammatory actions by stimulating the activation and expansion of regulatory T (Treg) cells by multiple mechanisms via antigen-presenting cells (APCs).