Electrocatalytic one pot synthesis of medicinally relevant 4H-benzo[g]chromene and pyrano[2, 3-g]chromene scaffold via multicomponent-domino approach. Issue 46 (15th November 2017)

• Record Type: Journal Article
• Authors: Upadhyay, Abhishek; Singh, Vinay K.; Dubey, Rahul; Kumar, Narendra; Sharma, L.K.; Singh, Rana Krishna Pal
• Is Part Of: Tetrahedron letters. Volume 58:Issue 46(2017)
• Page Start: 4323
• Page End: 4327
• Publication Date: 2017-11-15
• Subjects: 2-Amino-4H-benzo[g]chromene -- Multicomponent reaction -- Electrolysis -- Atom economy -- One pot; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2017.09.048
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: One pot four-component electro-synthesis of 1, 4-dihydropyrano[2, 3- c ]-pyrazole-5-carbonitrile derivatives. Electro-induced condensation of ethyl acetoacetate, hydrazine hydrate, malononitrile and aromatic aldehydes. EGB promotes reaction in presence of NaBr as supporting electrolyte and ethanol as solvent. Small amount of current was used as energy source in the place of conventional heating. Abstract: A highly efficient one pot, multicomponent synthesis of 4 H -benzo[ g ]chromene and pyrano[2, 3- g ]chromene derivatives are reported by electrochemically stimulated condensation of an aromatic aldehyde, malononitrile and some enolizable acidic compounds in ethanol at room temperature under constant current density. By utilizing common electrode materials and a simple constant current protocol, this method is a new alternative to conventional methods.