Breast metastasis nine years after nephrectomy for renal cell carcinoma: A case report. (2017)

• Record Type: Journal Article
• Authors: Ishigaki, Takayuki; Kinoshita, Satoki; Shimada, Naoko; Miyake, Ryo; Suzuki, Masaaki; Takeyama, Hiroshi
• Is Part Of: International journal of surgery case reports. Volume 39(2017)
• Page Start: 145
• Page End: 149
• Publication Date: 2017
• Subjects: RCC renal cell carcinoma -- CT computed tomography -- US ultrasonography -- FNA fine-needle aspiration -- CNB core-needle biopsy -- MRI magnetic resonance imaging -- ALND axillary lymph node dissection; Metastatic breast cancer -- Renal cell carcinoma -- Cryoablation; Surgery -- Periodicals; Surgical Procedures, Operative -- Periodicals; Surgery; Electronic journals; Periodicals; 617.005
• DOI: 10.1016/j.ijscr.2017.08.008
• Languages: English
• ISSNs: 2210-2612

Abstract

Highlights: We report an extremely rare case of breast metastasis from RCC. Including the present case, only 23 cases of breast metastasis from RCC have been described in the literature. It is important that the differential diagnosis of primary breast cancer and metastatic breast cancer be de determined by histological examination. Minimally invasive surgery or nonsurgical ablation should be performed in accordance with the prognosis. Abstract: Introduction: The breast is a rare site for metastatic disease. We report a rare case of breast metastasis 9 years after nephrectomy for renal cell carcinoma (RCC) and include a review of the relevant literature. Presentation of case: An 82-year-old woman who developed an RCC underwent left nephrectomy in 2005. In October 2014, computed tomography (CT) revealed a mass of approximately 1 cm in the lateral portion of the right breast. Breast ultrasonography (US) revealed a well-circumscribed, hypoechoic mass at the same site. Fine needle aspiration (FNA) was performed, but the sample was inadequate because it did not capture breast duct epithelial cells. In June 2015, follow-up US revealed enlargement of the mass, and core needle biopsy (CNB) was performed to confirm the diagnosis. Histological examination resulted in the diagnosis of breast metastasis from an RCC. The patient underwent surgery for partial mastectomy in November 2015. The patient was asymptomatic and free of detectable disease at 18-month follow-up. Discussion: The diagnosis of breast metastasis by imaging examination is difficult, and the results of FNA examination are often inconclusive because of the absence of breast duct epithelial cells. Only 22 cases of breast metastasis from RCC have been described in the literature. In almost all the reported cases, lumpectomy or partial mastectomy was performed. Conclusion: It is important that histological diagnosis be determined by CNB and by other methods if the patient has a history of malignancy, and minimally invasive therapy should be performed in accordance with the prognosis.