Long-term survival of a patient with advanced gastric cancer with paraaortic lymph node metastasis who attained pathological complete response after S-1/CDDP chemotherapy: A case report. (2017)

• Record Type: Journal Article
• Authors: Ushida, Yuta; Hiramatsu, Kiyoshi; Saeki, Satomi; Amemiya, Takeshi; Goto, Hidenari; Arai, Toshiyuki
• Is Part Of: International journal of surgery case reports. Volume 39(2017)
• Page Start: 260
• Page End: 263
• Publication Date: 2017
• Subjects: PAN paraaortic lymph node -- UICC Union for International Cancer Control -- EGD esophagogastroduodenoscopy -- CT computed tomography -- pCR pathological complete response; Gastric cancer -- Pathological complete response -- Paraaortic lymph node metastasis; Surgery -- Periodicals; Surgical Procedures, Operative -- Periodicals; Surgery; Electronic journals; Periodicals; 617.005
• DOI: 10.1016/j.ijscr.2017.08.016
• Languages: English
• ISSNs: 2210-2612

Abstract

Highlights: Gastric cancer with paraaortic lymph node (PAN) metastasis have unfavorable prognosis. A standard treatment for gastric cancer with PAN has yet to be determined. There are no evidence-based preoperative chemotherapy regimens available for them. A long-term survival case with PAN metastases attaining pCR is extremely rare. Abstract: Introduction: Gastric cancer with paraaortic lymph node (PAN) metastasis have unfavorable prognosis. There are no evidence-based preoperative chemotherapy regimens available. Case presentation: A 62-year-old female was diagnosed with advanced gastric cancer and PAN metastasis. We attempted S-1/CDDP chemotherapy in six coursed and total gastrectomy as well as systematic dissection of regional lymph nodes and PAN. Histologically, no cancerous cells were detected in specimens. The patient has been disease-free for 5 years since the surgery. Discussion: Long-term survival case of gastric cancer with PAN metastasis attaining pathologically complete response is extremely rare. It is possible that preoperative S1/CDDP with surgery might be a standard treatment strategy for gastric cancer with PANs. Conclusion: We report herein a rare case of gastric cancer with PAN metastases who achieved a 5-year survival after S-1/CDDP chemotherapy and surgery.