Novel Developments in the Prevention, Diagnosis, and Treatment of Periprosthetic Joint Infections. (April 2015)

• Record Type: Journal Article
• Authors: Parvizi, Javad; Alijanipour, Pouya; Barberi, Elie F.; Hickok, Noreen J.; Phillips, K. Scott; Shapiro, Irving M.; Schwarz, Edward M.; Stevens, Michelle H.; Wang, Yi; Shirtliff, Mark E.
• Is Part Of: Journal of the American Academy of Orthopaedic Surgeons. Volume 23(2015)Supplement 1
• Publication Date: 2015-04
• Subjects: Orthopedics -- Periodicals; Orthopedic surgery -- Periodicals; Joint Diseases -- Periodicals; Orthopedics -- Periodicals; Orthopedic surgery; Orthopedics; Periodicals; 616.7005
• DOI: 10.5435/JAAOS-D-14-00455
• Languages: English
• ISSNs: 1067-151X

Abstract

Abstract : Periprosthetic joint infection (PJI) is one of the most challenging complications compromising the outcome of an otherwise successful operation. Considerable efforts have been invested in the recent years to address paradigm shifts in our understanding of the complex microbiological phenomena that contribute to the pathophysiology of PJI, such as microbial adherence, biofilm formation, and resistance to antibiotics. This article is an introduction to some of the recent advancements in the prevention, diagnosis, and treatment of PJI. It describes how industry, academic researchers, and government are increasing collaboration to address PJI through development of novel technologies, therapeutic strategies, and regulatory science that specifically target the unique biofilm-associated aspects of its pathogenesis.