Can Oxidative Stress Parameters Be Used as Biomarkers for the Discrimination of Malignant Head and Neck Tumors. Issue 3 (May 2016)

• Record Type: Journal Article
• Authors: Dogan, Remzi; Meriç Hafiz, Ayşenur; Tugrul, Selahattin; Ozturan, Orhan; Keskin, Siddika; Kocyigit, Abdurrahim
• Is Part Of: Journal of craniofacial surgery. Volume 27:Issue 3(2016)
• Page Start: e316
• Page End: e320
• Publication Date: 2016-05
• Subjects: Benign -- head and neck tumor -- malignant -- oxidative stress -- total antioxidant status -- total oxidant status; Facial bones -- Surgery -- Periodicals; Skull -- Surgery -- Periodicals; Face -- Surgery -- Periodicals; Surgery, Plastic -- Periodicals; 617.52
• DOI: 10.1097/SCS.0000000000002575
• Languages: English
• ISSNs: 1049-2275

Abstract

Abstract : Objective: In this study the authors have investigated oxidative stress parameters in sera and tissues, and evaluated their significance for the differentiation of malignant and benign tumors. Methods: The study included 104 patients who were operated for head and neck tumors, and 45 healthy volunteers. Group 1 (n = 56) consisted of patients with malignant, Group 2 (n = 48) consisted of patients with benign tumors, and Group 3 (n = 45) was the control group. While both tissue and plasma samples were collected from groups 1 and 2, only plasma samples were collected from Group 3. Plasma and tissue levels of oxidative status were determined by using an automated measurement method. Results: Serum analysis revealed that total oxidant status (TOS) and oxidative stress index (OSI) values of Group 1 were significantly higher than those of Groups 2 and 3, and total antioxidant status (TAS) values of Group 1 were significantly lower than those of Groups 2 and 3. TAS values of Group 2 were lower than those of Group 3, but the difference was not statistically significant. Biochemical tissue analysis revealed that TOS and OSI values of Group 1 were significantly higher than those of Group 2, while TAS values of Group 1 were significantly lower than those of Group 2. Conclusions: There is a significant difference between the total oxidative stress parameters of malignant and benign head and neck tumors. The authors think that total oxidative stress parameters can be used as a practical, cheap, and easy method for discriminating malignant tumors from benign tumors.