Impact of a short exposure to levofloxacin on faecal densities and relative abundance of total and quinolone-resistant Enterobacteriaceae. (July 2016)

• Record Type: Journal Article
• Authors: Bernard, J.; Armand-Lefèvre, L.; Luce, E.; El Mniai, A.; Chau, F.; Casalino, E.; Andremont, A.; Ruppé, E.
• Is Part Of: Clinical microbiology and infection. Volume 22:Number 7(2016)
• Page Start: 646.e1
• Page End: 646.e4
• Publication Date: 2016-07
• Subjects: Antibiotic dosage -- Antibiotic impact -- Antibiotic resistance -- Escherichia coli -- Fluoroquinolones -- Intestinal microbiota -- Quantification; Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1016/j.cmi.2016.04.015
• Languages: English
• ISSNs: 1198-743X

Abstract

Abstract: Emergence of resistant Enterobacteriaceae in the intestinal microbiota during antibiotic treatment is well documented but its early dynamic is not. Here, we compared the densities of total Enterobacteriaceae and relative abundance (RA) of quinolone-resistant Enterobacteriaceae (QRE) in the first stool passed by patients who had a short exposure to levofloxacin (levofloxacin, n = 12) or not (control, n = 8). Mean densities (SD) (log CFU/g stool) of total Enterobacteriaceae were lower in the levofloxacin group than in the control group—3.4 (1.6) versus 6.7 (1.7), respectively, p <0.001. Conversely, mean RA (SD) of QRE was significantly higher in the levofloxacin group than in the control group—49.7% (23.4) versus 0.1% (3.2), respectively, p <0.05). In conclusion, even a short exposure to levofloxacin has a profound impact on the densities of total Enterobacteriaceae and the QRE-RA.