Cell-free DNA in pregnancy with choriocarcinoma and coexistent live fetus: A case report. Issue 37 (September 2016)

• Record Type: Journal Article
• Authors: Kristiansen, Mona Kjaerboel; Niemann, Isa; Lindegaard, Jacob Christian; Christiansen, Mette; Joergensen, Mette Warming; Vogel, Ida; Lildballe, Dorte Launholt; Sunde, Lone
• Other Names: Ma. Yufang section editor.
• Is Part Of: Medicine. Volume 95:Issue 37(2016)
• Publication Date: 2016-09
• Subjects: cell-free DNA -- choriocarcinoma -- coexistent pregnancy -- noninvasive diagnostics -- trophoblastic neoplasia; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000004721
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Background: This case report describes the use of analysis of cell-free DNA in the blood of a patient with a pregnancy with one live fetus and a choriocarcinoma diagnosed at 22 weeks of gestation. Results: The result of the analysis of 16 microsatellite loci on 14 chromosomes in the cell-free DNA in plasma was consistent with the result of the analysis of a tumor biopsy indicating biparental diploid origin of the genome. The DNA markers were discordant with the markers of the placenta indicating two separate conceptions. Conclusion: Our results indicate that analysis of cell-free DNA in plasma allows determination of the origin of a choriocarcinoma without tissue biopsy, even in the presence of a co-existent pregnancy.