Why cholecystokinin and gastrin are also incretins. Issue 3 (September 2016)

• Record Type: Journal Article
• Authors: Rehfeld, Jens F.
• Is Part Of: Cardiovascular endocrinology. Volume 5:Issue 3(2016:Sep.)
• Page Start: 99
• Page End: 101
• Publication Date: 2016-09
• Subjects: cholecystokinin -- gastrin -- gut hormones -- incretin -- insulin secretion; Cardiovascular system -- Diseases -- Periodicals; Endocrine glands -- Diseases -- Periodicals; Endocrinology -- Periodicals; Cardiovascular Diseases -- Periodicals; Endocrine System Diseases -- Periodicals; Cardiovascular system -- Diseases; Endocrine glands -- Diseases; Endocrinology; Periodicals; 616.1
• DOI: 10.1097/XCE.0000000000000095
• Languages: English
• ISSNs: 2162-688X

Abstract

Abstract : This review argues that cholecystokinin (CCK) and gastrin are incretins. The insulin cells are equipped with CCK2 /gastrin receptors. CCK/gastrin peptides stimulate insulin secretion and potentiate the incretin effect of glucagon-like peptide-1. CCK/gastrin and insulin are released in significant amounts during normal mixed meals even at modest changes in blood glucose concentrations. Treatment of diabetes patients with combinatorial glucagon-like peptide-1 and CCK or gastrin-derived constructs therefore provides an expedient option.