Type B insulin resistance syndrome. Issue 4 (August 2016)

• Record Type: Journal Article
• Authors: Willard, Devina L.; Stevenson, Mary; Steenkamp, Devin
• Is Part Of: Current opinion in endocrinology, diabetes and obesity. Volume 23:Issue 4(2016:Aug.)
• Publication Date: 2016-08
• Subjects: insulin receptor autoantibody -- syndromes of insulin resistance -- type B insulin resistance syndrome; Endocrinology -- Periodicals; Diabetes -- Periodicals; Obesity -- Periodicals; Diabetes Mellitus -- Periodicals; Endocrine System Diseases -- Periodicals; Endocrine Glands -- Periodicals; Obesity -- Periodicals; Endocrinologie -- Périodiques; Diabète -- Périodiques; Obésité -- Périodiques; Diabetes; Endocrinology; Obesity; Periodicals; 616.4
• DOI: 10.1097/MED.0000000000000263
• Languages: English
• ISSNs: 1752-296X

Abstract

Abstract : Purpose of review: To review the epidemiology, pathophysiology, clinical features, and management of type B insulin resistance syndrome. Recent findings: Type B insulin resistance syndrome is a rare disorder caused by autoantibodies to the insulin receptor. This disorder is most frequently reported in middle-aged black women and is invariably associated with other autoimmune diseases. Typically, refractory transient hyperglycemia and extreme insulin resistance are the cardinal features, but hypoglycemia may also occur. Traditionally, the high reported mortality rate was typically attributed to the hypoglycemia. There is no well standardized treatment regimen. However, recent therapeutic advances with combination immunomodulatory therapy have led to significant reported improvements in hypoglycemia-associated mortality and durability of remission. Summary: We review the literature on the pathophysiology and clinical features of type B insulin resistance syndrome and highlight the complexities and recent advances in the management of this disorder.