Palladium‐Catalyzed Domino Mizoroki–Heck/Intermolecular C(sp3)–H Activation Sequence: An Approach to the Formation of C(sp3)–C(sp3) Bonds. Issue 12 (19th March 2015)

• Record Type: Journal Article
• Authors: Wang, Wei; Zhou, Rong; Jiang, Zhi‐Jie; Wang, Xin; Fu, Hai‐Yan; Zheng, Xue‐Li; Chen, Hua; Li, Rui‐Xiang
• Is Part Of: European journal of organic chemistry. Issue 12(2015)
• Page Start: 2579
• Page End: 2584
• Publication Date: 2015-03-19
• Subjects: C‐H activation -- Cross‐coupling -- Dihydrobenzofuran -- Domino reactions -- Mizoroki–Heck reaction -- Palladium; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201500116
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: A palladium‐catalyzed domino Mizoroki–Heck/intermolecular unactivated C(sp 3 )–H alkylation reaction has been developed. This simple palladium nanoparticle catalytic system shows good activity and affords the dimeric dihydrobenzofuran derivatives in moderate to good yields. Furthermore, this reaction provides a new method for the elaboration of domino reactions involving a C(sp 3 )–C(sp 3 ) bond‐forming process. Abstract : A palladium‐catalyzed domino Mizoroki–Heck/intermolecular unactivated C(sp 3 )–H alkylation reaction is reported for the first time. This catalytic reaction provides an efficient method for the synthesis of dimeric dihydrobenzofurans from simple starting materials. This reaction provides a new method for the devising of domino reactions by including a C(sp 3 )–C(sp 3 ) bond‐forming reaction as a key step.