Methylene Blue for Burn-Induced Vasoplegia: Case Report and Review of Literature. Issue 2 (March 2015)

• Record Type: Journal Article
• Authors: Church, Joseph T.; Posluszny, Joseph A.; Hemmila, Mark; To, Kathleen B.; Cherry-Bukowiec, Jill R.; Waljee, Jennifer
• Is Part Of: Journal of burn care & research. Volume 36:Issue 2(2015)
• Publication Date: 2015-03
• Subjects: Burns and scalds -- Treatment -- Periodicals; Burns and scalds -- Periodicals; Burns -- Periodicals; Burns -- rehabilitation -- Periodicals; Research -- Periodicals; Brûlés -- Réadaptation -- Périodiques; Brûlures -- Prévention -- Périodiques; Burns and scalds -- Patients; Periodicals; 617.11005
• DOI: 10.1097/BCR.0000000000000134
• Languages: English
• ISSNs: 1559-047X

Abstract

Abstract : We report the use of a single dose of methylene blue in a patient with burn-induced vasoplegia refractory to fluids, vasopressors, and steroids. Administration of methylene blue allowed for cessation of epinephrine infusion within 2 hours of administration, and reduction in excessive fluid resuscitation. The patient's clinical course continued for 2 months and was complicated by severe acute respiratory distress syndrome, pneumonia, septic shock, poor skin graft adherence, renal failure requiring continuous renal replacement therapy, cutaneous mucormycosis, and ultimately, withdrawal of care and death. Despite the eventual outcome, this is the longest reported survival following methylene blue administration for vasoplegia secondary to burn injury.