Molecular markers in pituitary tumors. Issue 4 (August 2016)

• Record Type: Journal Article
• Authors: Robertson, Asha M.; Heaney, Anthony P.
• Is Part Of: Current opinion in endocrinology, diabetes and obesity. Volume 23:Issue 4(2016:Aug.)
• Publication Date: 2016-08
• Subjects: epigenetics and pituitary tumors -- micro-RNA and pituitary tumors -- molecular markers in pituitary tumors -- pituitary tumorigenesis; Endocrinology -- Periodicals; Diabetes -- Periodicals; Obesity -- Periodicals; Diabetes Mellitus -- Periodicals; Endocrine System Diseases -- Periodicals; Endocrine Glands -- Periodicals; Obesity -- Periodicals; Endocrinologie -- Périodiques; Diabète -- Périodiques; Obésité -- Périodiques; Diabetes; Endocrinology; Obesity; Periodicals; 616.4
• DOI: 10.1097/MED.0000000000000266
• Languages: English
• ISSNs: 1752-296X

Abstract

Abstract : Purpose of review: This review summarizes our current understanding of the mechanisms and factors involved in pituitary tumorigenesis. It provides a comprehensive review on the role of genetic mutations, epigenetics, oncogenes, tumor suppressor genes, cell cycle deregulation, and highlights recent findings of altered micro-RNA and long noncoding RNA expression in pituitary tumors. Recent findings: This article provides a concise summary of our knowledge regarding oncogenes, tumor suppressor genes, and cell cycle deregulation in pituitary tumors. Additionally, it highlights new findings in epigenetics and altered micro-RNA and long noncoding RNA expression in pituitary tumors. Summary: Improved understanding of the mechanism(s) and candidates implicated in pituitary tumorigenesis may result in the identification of new therapeutic targets in pituitary tumors.