Impacts of laparoscopic hysterectomy on functions of coagulation and fibrinolysis system. Issue 4 (June 2016)

• Record Type: Journal Article
• Authors: Zhao, Honghui; Xiao, Wei; Hu, Chunjie; Gao, Xiaoxu; Zhu, Yumei; Yang, Xiaofeng
• Is Part Of: Blood coagulation and fibrinolysis. Volume 27:Issue 4(2016)
• Publication Date: 2016-06
• Subjects: coagulation -- fibrinolysis -- hysterectomy -- laparoscopy; Blood -- Coagulation -- Periodicals; Fibrinolysis -- Periodicals; Hemostasis -- Periodicals; Thrombosis -- Periodicals; Blood Coagulation -- Periodicals; Fibrinolysis -- Periodicals; Hemostasis -- Periodicals; Thrombosis -- Periodicals; 612.115
• DOI: 10.1097/MBC.0000000000000447
• Languages: English
• ISSNs: 0957-5235

Abstract

Abstract : The main objective of the study is to compare the impacts of laparoscopic hysterectomy and total abdominal hysterectomy on the functions of coagulation and fibrinolysis system. Seventy-five patients who had undergone hysterectomy were randomly divided into laparoscopic hysterectomy group ( n = 38) and total abdominal hysterectomy group ( n = 37). The prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen, D-dimer, von Willebrand factor, α-granule membrane protein-140, thrombin-activated fibrinolysis inhibitor (TAFI) and platelet count were detected at preoperative 24 h (N0), postoperative 24 h (N1) and postoperative 48 h (N2). Compared with N0, values of PT, APTT and TT were significantly decreased at N1 in both groups, whereas von Willebrand factor, platelet count and α-granule membrane protein-140 levels at N1 were significantly increased ( P < 0.05). There was no significant difference between N0 and N2 ( P > 0.05). Compared with N0, fibrinogen, D-dimer and TAFI levels in both groups were significantly higher at N1 ( P < 0.05), and there was no significant difference between N0 and N2 ( P > 0.05). The intergroup comparison showed no significant difference of above indexes between two groups ( P > 0.05). The univariate analysis showed that TAFI was negatively correlated with TT ( r = −0.365, P < 0.01), APTT ( r = −0.183, P < 0.05) and PT ( r = −0.121, P < 0.05), whereas not correlated with other indicators. Laparoscopic hysterectomy may increase the risk of postoperative venous thrombosis.