Clinicoradiological characteristics of patients with differentiated thyroid carcinoma and renal metastasis: case series with follow up. Issue 2 (30th January 2014)

• Record Type: Journal Article
• Authors: Kand, P; Basu, S
• Is Part Of: Journal of laryngology & otology. Volume 128:Issue 2(2014)
• Page Start: 203
• Page End: 208
• Publication Date: 2014-01-30
• Subjects: Thyroid Carcinoma, -- Neoplasm Metastasis, -- Kidney, -- Fluorodeoxyglucose F18, -- Positron Emission Tomography, -- Tomography, -- X-Ray Computed; Otolaryngology -- Periodicals; 617.51
• DOI: 10.1017/S0022215113003617
• Languages: English
• ISSNs: 0022-2151

Abstract

Abstract: Background: Renal metastasis is relatively unusual in patients with differentiated thyroid carcinoma. Methods: The clinicoradiological parameters of a series of patients with differentiated thyroid carcinoma and renal metastasis were assessed, together with follow-up data. Results and conclusion: The series comprised 4 male patients over the age of 45 years with extensive disease at the primary site. Retro-sternal extension of a large goitre was observed in three patients. The primary tumour was 4 cm or larger in all patients (range, 4–14 cm), and three patients had associated lymph node metastasis. None had any genito-urinary symptoms at presentation. Two patients had isolated renal metastases with no other distant metastases, while the others had extensive multi-organ involvement. The bilateral occurrence of lesions was a hallmark, being observed in all cases. Ultrasound-guided fine needle aspiration cytology and 131 I scintigraphy were pivotal in confirming the diagnosis. Evidence of 'flip-flop' between 131 I study and fluoro-deoxyglucose positron emission tomography was noted in one patient, while the other three demonstrated concordant lesions in both modalities. At a minimum follow-up period of four years after diagnosis, three patients demonstrated stable disease with radioiodine therapy, and one had expired due to a poorly differentiated lung carcinoma which developed subsequently.