AT1 receptor signaling pathways in the cardiovascular system. (November 2017)

• Record Type: Journal Article
• Authors: Kawai, Tatsuo; Forrester, Steven J.; O'Brien, Shannon; Baggett, Ariele; Rizzo, Victor; Eguchi, Satoru
• Is Part Of: Pharmacological research. Volume 125(2017:Nov.)Part A
• Page Start: 4
• Page End: 13
• Publication Date: 2017-11
• Subjects: AAA abdominal aortic aneurysm -- ADAM17 a disintegrin and metalloproteinase 17 -- ANO1 anoctamin-1 -- ARAP1 type 1 angiotensin II receptor-associated protein -- ATRAP AT1 receptor associated protein -- AngII angiotensin II -- AT1 receptor angiotensin II type 1 receptor -- AT2 receptor angiotensin II type 2 receptor -- β-COP Coatomer subunit β -- BMX bone marrow kinase -- CHKA choline kinase alpha -- COPI Coat Protein I -- Drp1 dynamin-related protein 1 -- EC endothelial cells -- EGF epidermal growth factor -- EGFR epidermal growth factor receptor -- eIF4E eukaryotic translation initiation factor 4E -- eNOS endothelial nitric oxide synthase -- ER endoplasmic reticulum -- ERK extracellular signal regulated kinase -- GABA Gamma-aminobutyric acid -- GABARAP Gamma-aminobutyric acid receptor-associated protein -- GEF Guanine nucleotide exchange factor -- GLP GEF-like protein -- GPCR G protein-coupled receptor -- GRK G protein-coupled receptor kinase -- HB-EGF Heparin-binding EGF-like growth factor -- HIF-1α hypoxia-inducible factor 1 alpha -- IGF-1R insulin-like growth factor-1 receptor -- JAK2 Janus kinase 2 -- JNK c-Jun N terminal kinase -- LATS large tumor suppressor kinase -- MAPK mitogen-activated protein kinase -- MEK MAPK/ERK kinase -- MCP-1 monocyte chemoattractant protein-1 -- MFN2 Mitofusion 2 -- MLCK myosin light chain kinase -- MLCP myosin light chain phosphatase -- mTOR mechanistic target of rapamycin -- NADPH nicotinamide adenine dinucleotide phosphate -- NF-kB nuclear factor kappa B -- NFAT Nuclear factor of activated T-cells -- NKCC1 Na-K-Cl cotransporter isoform 1 -- NLRP3 NLR family pyrin domain containing 3 -- NO nitric oxide -- oxLDL oxidized low density lipoprotein -- PAI-1 plasminogen activator inhibitor-1 -- PAK1 p21-activated kinase 1 -- PARP poly (ADP-ribose) polymerase -- PDGFR platelet-derived growth factor receptor -- PI3K phosphatidylinositol 3-kinase -- PKA protein kinase A -- PKB protein kinase B -- PKC protein kinase C -- PLC phospholipase C -- PPARγ peroxisome proliferator-activated receptor gamma -- RAAS renin-angiotensin-aldosterone system -- RANKL receptor activator of nuclear factor-kappa B -- RAP1b Ras-related protein -- ROCK Rho-associated protein kinase -- ROS reactive oxygen species -- SOD superoxide dismutase -- SPAK Ste20/SPS1-related proline/alanine-rich kinase -- TAA thoracic aortic aneurysm -- TCF/LEF (T-cell factor/lymphoid enhancer factor) -- TGFβ1 transforming growth factor beta 1 -- TRIO triple functional domain (PTPRF interacting) -- VSMC vascular smooth muscle cells -- WISP1 Wnt1 inducible signaling pathway protein 1 -- WNK with-no-lysine -- YAP Yes-associated protein; Angiotensin II -- Signal transduction -- Vascular smooth muscle cell -- Endothelial cell -- ADAM17 -- EGF receptor; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2017.05.008
• Languages: English
• ISSNs: 1043-6618

Abstract

Abstract: The importance of the renin angiotensin aldosterone system in cardiovascular physiology and pathophysiology has been well described whereas the detailed molecular mechanisms remain elusive. The angiotensin II type 1 receptor (AT1 receptor) is one of the key players in the renin angiotensin aldosterone system. The AT1 receptor promotes various intracellular signaling pathways resulting in hypertension, endothelial dysfunction, vascular remodeling and end organ damage. Accumulating evidence shows the complex picture of AT1 receptor-mediated signaling; AT1 receptor-mediated heterotrimeric G protein-dependent signaling, transactivation of growth factor receptors, NADPH oxidase and ROS signaling, G protein-independent signaling, including the β-arrestin signals and interaction with several AT1 receptor interacting proteins. In addition, there is functional cross-talk between the AT1 receptor signaling pathway and other signaling pathways. In this review, we will summarize an up to date overview of essential AT1 receptor signaling events and their functional significances in the cardiovascular system.