Use of Extracorporeal Techniques in the Removal of Dabigatran. (March 2016)

• Record Type: Journal Article
• Authors: Muddana, Neeharika; Thuyanh, Culver; Nayer, Ali; Nashar, Khaled; Ortega, Luis M.
• Is Part Of: American journal of therapeutics. Volume 23:Number 2(2016)
• Publication Date: 2016-03
• Subjects: dabigatran -- thrombin inhibitors -- toxicity -- renal replacement therapy -- dialysis -- bleeding; Chemotherapy -- Periodicals; Pharmacology -- Periodicals; 615.58
• DOI: 10.1097/MJT.0000000000000082
• Languages: English
• ISSNs: 1075-2765

Abstract

Abstract : Dabigatran is a novel direct thrombin inhibitor that has proven effective in the prevention of vascular events in patients with nonvalvular atrial fibrillation. Not much is known about the clearance capability with extracorporeal techniques of dabigatran. This review showcases the pharmacokinetics and a perusal of the current literature regarding cases that involved the clearance of the drug in patients with normal renal function and end-stage renal disease. Renal replacement therapy represents a therapeutic option to eliminate dabigatran and decreased the risk of bleeding in patients undergoing emergent surgical procedures on dabigatran.