Intractable Polyuria Mimicking Diabetes Insipidus—Source Traced to Vecuronium Infusion. (March 2016)

• Record Type: Journal Article
• Authors: Haldar, Rudrashish; Samanta, Sukhen; Singla, Ankush
• Is Part Of: American journal of therapeutics. Volume 23:Number 2(2016)
• Publication Date: 2016-03
• Subjects: vecuronium -- infusion -- mannitol -- polyuria; Chemotherapy -- Periodicals; Pharmacology -- Periodicals; 615.58
• DOI: 10.1097/MJT.0000000000000057
• Languages: English
• ISSNs: 1075-2765

Abstract

Abstract : Continuous infusion of vecuronium is a commonly used technique for patients requiring prolonged neuromuscular blockade for mechanical ventilation. As compared with older neuromuscular blocking agents, it confers the advantages of rapid excretion and intermediate duration of action. Prolongation of neuromuscular blockade and muscle weakness are the known complications of continuous vecuronium infusion. This report attempts to describe polyuria, as a hitherto unknown complication of vecuronium infusion, which can occur due to the mannitol present in commercially available preparation of vecuronium bromide.