Hypothermia for Traumatic Brain Injury in Children—A Phase II Randomized Controlled Trial. Issue 2 (April 2016)

• Record Type: Journal Article
• Authors: Beca, John; McSharry, Brent; Erickson, Simon; Yung, Michael; Schibler, Andreas; Slater, Anthony; Wilkins, Barry; Singhal, Ash; Williams, Gary; Sherring, Claire; Butt, Warwick
• Is Part Of: Survey of anesthesiology. Volume 60:Issue 2(2016)
• Publication Date: 2016-04
• Subjects: Anesthesiology -- Periodicals; 617.96
• DOI: 10.1097/01.sa.0000480638.52912.6f
• Languages: English
• ISSNs: 0039-6206

Abstract

Abstract : Surv Anesthesiol 2016;60(2):73–74 This pilot study was undertaken to test the hypothesis that early and prolonged therapeutic hypothermia (TH; continued for a minimum of 72 hours, with rate of rewarming guided by intracranial pressure [ICP] and cerebral perfusion pressure [CPP]) would improve the outcome in children with traumatic brain injury (TBI). This multicenter trial, conducted in all 8 of the pediatric intensive care units (PICUs) in Australia and New Zealand and 1 in Canada, tested the protocol (including adherence, safety, and outcomes) in order to assess the feasibility of a phase III randomized controlled trial (RCT).