On Naivety of T Cells in Inflammatory Bowel Disease: A Review. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Smids, Carolijn; Horjus Talabur Horje, Carmen S.; Wahab, Peter J.; Groenen, Marcel J. M.; Middendorp, Sabine; van Lochem, Ellen G.
• Is Part Of: Inflammatory bowel diseases. Volume 21:Issue 1(2015:Jan.)
• Publication Date: 2015-01
• Subjects: Crohn's disease -- ulcerative colitis -- T-cell subsets -- naive T cells -- tertiary lymphoid organ; Inflammatory bowel diseases -- Periodicals; Colitis, Ulcerative -- Periodicals; Crohn Disease -- Periodicals; Inflammatory Bowel Diseases -- Periodicals; 616.344
• DOI: 10.1097/MIB.0000000000000221
• Languages: English
• ISSNs: 1078-0998

Abstract

Abstract : Abstract: Little is known about different phases of T-cell maturation in gut mucosa. Based on current knowledge about the migratory pathways of naive and memory T cells, it is believed that access to peripheral, nonlymphoid tissues is restricted to memory T cells. Surprisingly, there is increasing evidence of high numbers of naive T cells in the chronically inflamed gut tissue of patients with inflammatory bowel disease. This could partially be explained by new formation of ectopic lymphoid organs. Ongoing recruitment of naive T cells at inflammatory sites might play a role in the immunopathogenesis of inflammatory bowel disease. Abstract : Article first published online 29 September 2014.